Your Challenges Require Smart Solutions:

In Vivo DMPK

Flexibility & Speed

Flexibility in study design and meeting demanding time lines is the strength of the Pharmacelsus In Vivo team. We offer DMPK studies in mice, rats, guinea pigs and hamsters. Further preclinically relevant species (e.g. dog, monkey) are available in cooperation with our partners. The Pharmacelsus offering includes complete workflow studies (in-life part, bioanalysis and PK evaluation).

Species

Rodents
Non-Rodents*

*in cooperation

Application Routes

Intravenous (Bolus or Infusion)
Oral (Liquid, Capsules)
Intraperitoneal
Subcutaneous (incl. Osmotic - Minipumps)
Intramuscular
Intradermal
Intranasal
Topical
Intravitreal
Intraportal
Single, Repeated and Cassette Dosing

Exploratory PK Studies

Microsampling/Snapshot PK
Cassette Dosing
Major Metabolites

Surgical Methods

Cannulation (Rat)
- Vena Jugularis (Neck or Head Attachment)
- Portal Vein* (e.g. for Evaluation of First-Pass Effect)
- Bile Duct* (e.g. for Evaluation of Entero-Hepatic Circulation)
Bile Duct Ligation (Rat)
Castration

*animal surgery is conducted at the provider of rats and mice.

Sampling Methods

Jugular Catheter
Tail Vein or Artery
Sublingual Vein
Facial Vein
Plexus Retrobulbaris
Heart Puncture (Terminal)
Microsampling
Tissue Perfusion
Metabolic Cage

Sample Types

Whole Blood, Plasma, Dried Blood Spots
Excreta
- Urine
- Faeces
- Bile
Bronchioalveolare Lavage Fluid
Cerebrospinal Fluid
Tissues/Organs

Biomarkers

All Markers that can be Quantified in Biological Matrices by Validated Immuno-Assay or LC-MS-Methods
Sample Processing for Histology
Haematology

Full PK Studies

Dose Proportionality
Organ Distribution, Excretion, Mass - Balance
Metabolite Identification
First Pass Effect

Ex Vivo Investigation

Brain Slice Method

All experimental procedures are approved by and conducted in accordance with the regulations of the local Animal Welfare authorities. The Pharmacelsus In Vivo department is frequently audited by clients with positive results.

Please contact us for your specific DMPK study.

MUDr. Maria Li
 Director Business Development
li@pharmacelsus.de

Anika Christoffel 
In Vivo Pharmacology & Pharmacokinetics 
christoffel@pharmacelsus.de